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Arrhenoblastoma of ovary

  • Definition
  • Alternative Names
    • Stromal tumor; Gonadal stromal tumor; Sex cord tumor; Androblastoma

  • Causes
    • This is a rare tumor. It accounts for less than 0.5% of all ovarian tumors.

      These tumors are found in women of all age groups, but are most common in young women.

  • Symptoms
    • This tumor releases male hormones, which cause the following symptoms in women:

      • Deepening of the voice
      • Increased acne
      • Increased hair on the face and body
      • Increased size of the clitoris
      • Male pattern baldness
  • Exams and Tests
    • The following tests are used to diagnose the condition:

      • Blood tests to check levels of hormones that may be released by the tumor
      • CT scan of the pelvis and abdomen to see if the tumor has spread
      • Ultrasound of the ovaries
  • Treatment
    • Surgery to remove the tumor is the main treatment. If the cancer has spread, chemotherapy or radiation therapy may be considered.

  • Support Groups
    • You can ease the stress of illness by joining a support group where members share common experiences and problems.

  • Outlook (Prognosis)
    • The outcome of this disease depends on whether it has spread, and whether surgery can completely remove the tumor.

      Arrhenoblastoma has a low chance of spreading. If the tumor is found early, the cure rate can be very good.

  • Possible Complications
    • Complications may include:

      • Complications of surgery
      • Masculine symptoms (virilization)
      • Spread of the tumor if it is not completely removed
  • When to Contact a Medical Professional
    • Call your health care provider if you are a woman and have masculine symptoms. Also call if you feel a lump in your lower belly area.

  • Prevention
    • There is no good screening test. Regular gynecologic exams and recognizing masculine symptoms may help detect the disease.

  • References
    • Bulun SE. The physiology and pathology of the female reproductive axis. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 13th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 17.

      Lobo RA. Hyperandrogenism. In: Lentz GM, Lobo RA, Gershenson DM, Katz VL, eds. Comprehensive Gynecology. 6th ed. Philadelphia, PA: Elsevier Mosby; 2012:chap 40.