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IgA nephropathy

  • Definition
    • IgA nephropathy is a kidney disorder in which antibodies called IgA build up in kidney tissue. Nephropathy is damage, disease, or other problems with the kidney.

      IgA nephropathy is also called Berger disease.

  • Alternative Names
    • Nephropathy - IgA; Berger disease

  • Causes
    • IgA is a protein, called an antibody, that helps the body fight infections. IgA nephropathy occurs when too much of this protein is deposited in the kidneys. IgA builds up inside the small blood vessels of the kidney. Structures in the kidney called glomeruli become inflamed and damaged.

      The disorder can appear suddenly (acute), or get worse slowly over many years (chronic glomerulonephritis).

      Risk factors include:

      • A personal or family history of IgA nephropathy or Henoch Schonlein purpura, a form of vasculitis that affects many parts of the body
      • White or Asian ethnicity

      IgA nephropathy can occur in people of all ages, but it most often affects males in their teens to late 30s.

  • Symptoms
    • There may be no symptoms for many years.

      When there are symptoms, they may include:

      • Bloody urine that starts during or soon after a respiratory infection
      • Repeated episodes of dark or bloody urine
      • Swelling of the hands and feet
      • Symptoms of chronic kidney disease
  • Exams and Tests
    • IgA nephropathy is most often discovered when a person with no other symptoms of kidney problems has one or more episodes of dark or bloody urine.

      There are no specific changes seen during a physical examination. Sometimes, the blood pressure may be high or there may be swelling of the body.

      Tests include:

  • Treatment
    • The goal of treatment is to relieve symptoms and prevent or delay chronic renal failure.

      You may get medicines to control high blood pressure and swelling (edema), such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). Controlling blood pressure is the most important way to delay kidney damage.

      Corticosteroids, other drugs that suppress the immune system, and fish oil have also been used to treat this disorder.

      Salt and fluids may be restricted to control swelling. A low-to-moderate protein diet may be recommended in some cases.

      Some people need to take medicines to lower their cholesterol.

      Eventually, many people must be treated for chronic kidney disease and may need dialysis.

  • Support Groups
    • For additional information and support, see the IgA Nephropathy Support Network website (www.igansupport.org).

  • Outlook (Prognosis)
    • IgA nephropathy gets worse slowly. In many cases, it does not get worse at all. Your condition is more likely to get worse if you have:

  • When to Contact a Medical Professional
    • Call your health care provider if you have bloody urine or if you are producing less urine than usual.

  • References
    • Feehally J, Floege J. IgA nephropathy and Henoch-Schonlein nephritis. In: Johnson RJ, Feehally J, Floege J, eds. Comprehensive Clinical Nephrology. 5th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 23.

      Ferri FF. IgA nephropathy. In: Ferri FF, ed. Ferri's Clinical Advisor 2016. Philadelphia, PA: Elsevier; 2016:691-692.