Renal cell carcinoma

  • Definition
    • Renal cell carcinoma is a type of kidney cancer that starts in the lining of very small tubes (tubules) in the kidney.

  • Alternative Names
    • Renal cancer; Kidney cancer; Hypernephroma; Adenocarcinoma of renal cells; Cancer - kidney

  • Causes
    • Renal cell carcinoma is the most common type of kidney cancer in adults. It occurs most often in men 50 to 70 years old.

      The exact cause is unknown.

      The following may increase your risk of kidney cancer:

      • Smoking
      • Obesity
      • Dialysis treatment
      • Family history of the disease
      • High blood pressure
      • Horseshoe kidney
      • Long-term use of certain medicines, such as pain pills or water pills (diuretics)
      • Polycystic kidney disease
      • Von Hippel-Lindau disease (a hereditary disease that affects blood vessels in the brain, eyes, and other body parts)
  • Symptoms
  • Exams and Tests
  • Treatment
    • Surgery to remove of all or part of the kidney (nephrectomy) is recommended. This may include removing the bladder, surrounding tissues, or lymph nodes. A cure is unlikely unless all of the cancer is removed with surgery. But even if some cancer is left behind, there is still benefit from surgery.

      Chemotherapy is generally not effective for treating kidney cancer. The immune system medicines interleukin-2 (IL-2) or nivolumab may help some people. Medicines that target the development of blood vessels that feed the tumor may be used to treat kidney cancer. Your provider can tell you more.

      Radiation therapy usually does not work for kidney cancer.

  • Support Groups
    • You can ease the stress of illness by joining a support group whose members share common experiences and problems.

  • Outlook (Prognosis)
    • Sometimes, both kidneys are involved. The cancer spreads easily, most often to the lungs and other organs. In about one third of people, the cancer has already spread (metastasized) at the time of diagnosis.

      How well someone with kidney cancer does depends on how much the cancer has spread and how well treatment works. The survival rate is highest if the tumor is in the early stages and has not spread outside the kidney. If it has spread to the lymph nodes or to other organs, the survival rate is much lower.

  • Possible Complications
    • Complications of kidney cancer include:

      • High blood pressure (hypertension)
      • Too much calcium in the blood
      • High red blood cell count
      • Liver problems
      • Spread of the cancer
  • When to Contact a Medical Professional
    • Call your provider any time you see blood in the urine. Also call if you have any other symptoms of this disorder.

  • Prevention
    • Stop smoking. Follow your provider's recommendations in the treatment of kidney disorders, especially those that may require dialysis.

  • References
    • Campbell SC, Lane BR. Malignant renal tumors. In: Wein AJ, Kavoussi LR, Partin AW, et al, eds. Campbell-Walsh Urology. 11th ed. Philadelphia, PA: Elsevier; 2016:chap 57.

      National Cancer Institute: PDQ renal cell cancer treatment. Bethesda, MD: National Cancer Institute. Date last modified: February 4, 2016. Accessed: February 1, 2016.

      National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: kidney cancer. Version 2. 2016. Accessed: March 17, 2016.

      Pili R, Kauffman E, Rodriguez R. Cancer of the kidney. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 82.