Factor V deficiency

  • Definition
    • Factor V deficiency is a condition that is passed down through families, which affects the ability of the blood to clot.

  • Alternative Names
    • Parahemophilia; Owren disease; Bleeding disorder - Factor V deficiency

  • Causes
    • Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors.

      Factor V deficiency is caused by a lack of Factor V. When certain blood clotting factors are low or missing, your blood does not clot properly.

      Factor V deficiency is rare. It may be caused by:

      • A defective Factor V gene passed down through families (inherited)
      • An antibody that interferes with normal Factor V function

      You can get an antibody that interferes with Factor V:

      • After giving birth
      • After being treated with a certain type of fibrin glue
      • After surgery
      • With autoimmune diseases and certain cancers

      Sometimes the cause is unknown.

      The disease is similar to hemophilia, except bleeding into joints is less common. In the inherited form of Factor V deficiency, a family history of a bleeding disorder is a risk factor.

  • Symptoms
    • Excessive bleeding with menstrual periods and after childbirth often occurs. Other symptoms can include:

  • Exams and Tests
  • Treatment
    • You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.

  • Outlook (Prognosis)
    • The outlook is good with diagnosis and proper treatment.

  • Possible Complications
    • Severe bleeding (hemorrhage) could occur.

  • When to Contact a Medical Professional
    • Go to the emergency room or call the local emergency number (such as 911) if you have an unexplained or prolonged loss of blood.

  • References
    • Gailani D, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 139.

      Ragni MV. Hemorrhagic disorders In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 174.

      Scott JP, Flood VH. Hereditary clotting factor deficiencies (bleeding disorders). In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 476.