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Waterhouse-Friderichsen syndrome

  • Definition
    • Waterhouse-Friderichsen syndrome (WFS) is a collection of symptoms resulting from the failure of the adrenal glands to function normally as a result of bleeding into the gland.

  • Alternative Names
    • Fulminant meningococcemia - Waterhouse-Friderichsen syndrome; Fulminant meningococcal sepsis - Waterhouse-Friderichsen syndrome; Hemorrhagic adrenalitis

  • Causes
    • The adrenal glands are 2 triangle-shaped glands. One gland is located on top of each kidney. The adrenal glands produce and release different hormones that the body needs to function normally. The adrenal glands can be affected by many diseases, such as infections like WFS.

      WFS is caused by severe infection with meningococcus bacteria or other severe infection from bacteria, such as:

      • Group B streptococcus
      • Pseudomonas aeruginosa
      • Streptococcus pneumoniae
      • Staphylococcus aureus
  • Symptoms
    • Symptoms and signs usually come on very suddenly. They are due to the bacteria growing (multiplying) inside the body. Symptoms include:

      • Fever and chills
      • Joint and muscle pain
      • Headache
      • Vomiting

      Infection with bacteria causes bleeding throughout the body, which causes:

      Bleeding into the adrenal glands causes adrenal crisis, in which not enough adrenal hormones are produced. This leads to symptoms such as:

      • Dizziness, weakness
      • Very low blood pressure
      • Very fast heart rate
      • Confusion or coma
  • Exams and Tests
  • Treatment
    • Treatment involves giving antibiotics as soon as possible to treat the bacterial infection. Glucocorticoid medicines will also be given to treat adrenal gland problem. Supportive treatments will be needed for other symptoms.

  • Outlook (Prognosis)
    • WFS is fatal unless treatment for the bacterial infection is started right away.

  • Possible Complications

  • Prevention
    • To prevent WFS caused by meningococcal bacteria, a vaccine is available.

  • References
    • Stephens DS, Apicella MA. Neisseri meningitides. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 8th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 213.

      Stewart PM. Krone NP. The adrenal cortex. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 15.