• Definition
    • Endocarditis is inflammation of the inside lining of the heart chambers and heart valves (endocardium). It is caused by a bacterial or, rarely a fungal infection.

  • Alternative Names
    • Valve infection; Staphylococcus aureus - endocarditis; Enterococcus - endocarditis; Streptococcus viridans - endocarditis; Candida - endocarditis

  • Causes
    • Endocarditis can involve the heart muscle, heart valves, or lining of the heart. Some people who develop endocarditis have a:

      Endocarditis begins when germs enter the bloodstream and then travel to the heart.

      • Bacterial infection is the most common cause of endocarditis.
      • Endocarditis can also be caused by fungi, such as Candida.
      • In some cases, no cause can be found.

      Germs are most likely to enter the bloodstream during:

      • Central venous access lines
      • Injection drug use, from the use of unclean (unsterile) needles
      • Recent dental surgery
      • Other surgeries or minor procedures to the breathing tract, urinary tract, infected skin, or bones and muscles
  • Symptoms
    • Symptoms of endocarditis may develop slowly or suddenly.

      Fever, chills, and sweating are frequent symptoms. These sometimes can:

      • Be present for days before any other symptoms appear
      • Come and go, or be more noticeable at nighttime

      You may also have fatigue, weakness, and aches and pains in the muscles or joints.

      Other signs can include:

      • Small areas of bleeding under the nails (splinter hemorrhages)
      • Red, painless skin spots on the palms and soles (Janeway lesions)
      • Red, painful nodes in the pads of the fingers and toes (Osler's nodes)
      • Shortness of breath with activity
      • Swelling of feet, legs, abdomen
  • Exams and Tests
  • Treatment
    • You may need to be in hospital to get antibiotics through a vein (IV or intravenously). Blood cultures and tests will help your provider choose the best antibiotic.

      You will then need long-term antibiotic therapy.

      • People most often need therapy for 4 to 6 weeks to fully kill all the bacteria from the heart chambers and valves.
      • Antibiotic treatments that are started in the hospital will need to be continued at home.

      Surgery to replace the heart valve is usually needed when:

      • The infection is breaking off in little pieces, resulting in strokes.
      • The person develops heart failure as a result of damaged heart valves.
      • There is evidence of more severe organ damage.
  • Outlook (Prognosis)
    • Getting treatment for endocarditis right away improves the chances of a good outcome.

      More serious problems that may develop include:

      • Brain abscess
      • Further damage to the heart valves, causing heart failure
      • Spread of the infection to other parts of the body
      • Stroke, caused by small clots or pieces of the infection breaking off and traveling to the brain
  • When to Contact a Medical Professional
    • Call your health care provider if you notice the following symptoms during or after treatment:

      • Blood in urine
      • Chest pain
      • Fatigue
      • Fever
      • Numbness
      • Weakness
      • Weight loss without change in diet
  • Prevention
    • The American Heart Association recommends preventive antibiotics for people at risk for infectious endocarditis, such as those with:

      • Certain birth defects of the heart
      • Heart transplant and valve problems
      • Man-made (prosthetic) heart valves
      • Past history of endocarditis

      These people should receive antibiotics when they have:

      • Dental procedures that are likely to cause bleeding
      • Procedures involving the breathing tract
      • Procedures involving the urinary tract system
      • Procedures involving the digestive tract
      • Procedures on skin infections and soft tissue infections
  • References
    • Baddour LM, Freeman WK, Suri RM, Wilson WR. Cardiovascular infections. In: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 64.

      Fowler VG Jr, Scheld WM, Bayer AS. Endocarditis and Intravascular Infections. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2009; chapt 77.

      Wilson W, Taubert KA, Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007 Oct 9;116(15):1736-54.