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The purpose of this study is to evaluate the feasibility of switching patients from the standard dual antiplatelet therapy (DAPT) to single therapy of Ticagrelor or Prasugrel only or DAPT with Clopidogrel and Aspirin and to compare how platelets stick together with all of these treatment regimens.


Protocol number IRB202202835


Inclusion criteria:

Patients who presented with chronic coronary syndrome, underwent PCI and have been on maintenance treatment with DAPT, composed of low-dose aspirin (81mg od) and prasugrel (10 mg od) or ticagrelor (90 mg bid) for at least 30 days. Or patients that presented with an Acute coronary syndrome (ACS) event and underwent PCI and have been on maintenance treatment with DAPT, composed of low-dose aspirin (81mg od) and prasugrel (10mg od) or ticagrelor (90mg bid) for 3 months or greater. Age 18 – 100 years old Provide written informed consent


Exclusion criteria:

Prior history of stent thrombosis Acute Coronary Syndrome (ACS) within 3 months. On treatment with any oral anticoagulant (vitamin K antagonists, dabigatran, rivaroxaban, apixaban, edoxaban) or chronic low-molecular-weight heparin (at venous thrombosis treatment, not for prophylaxis) Renal failure requiring dialysis Patients with known bleeding diathesis or coagulation disorders Known severe hepatic impairment Hemodynamic instability Hypersensitivity to clopidogrel Pregnant and breastfeeding women [women of childbearing age must use reliable birth control (i.e., oral contraceptives) while participating in the study]

Lead researcher

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  1. Step

    Contact the research team

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    Primary contact

  2. Step

    Get screened to confirm eligibility

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  3. Step

    Provide your consent to participate

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  4. Step


    If you decide to participate in a clinical trial or study, the research team will keep you informed of the study requirements and what you will need to do to throughout the study. For some trials or studies, your health care provider may work with the research team to ensure there are no conflicts with other medications or treatments.