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Founded in 1988, the Jacksonville campus of the University of Florida Academic Health Center is home to more than 2,000 UF faculty, residents, fellows, staff and administrators. The center is co-located with the UF Health Jacksonville hospital on a campus that encompasses more than 10 city blocks.

The colleges of medicine, nursing and pharmacy all have a major presence on the Jacksonville campus.

The UF College of Medicine – Jacksonville offers 39 different residency and fellowship programs and, in 2011, more than a third of graduates stayed in Northeast Florida to begin their careers. Overall, UF graduate medical education (GME) programs support 395 residents and fellows at UF Health Jacksonville. As such, the size and scope of GME on the Jacksonville campus ranks third in Florida, behind only UF Health Shands Hospital in Gainesville and University of Miami/Jackson Memorial Hospital in Miami. In addition, the campus offers clinical clerkships to third- and fourth-year UF medical students.

In addition to residents, fellows and medical students, there are 200 UF College of Pharmacy students and 85 UF College of Nursing students on campus, providing a ready source of health professionals in these disciplines for the region. Aside from the UF Health campus in Gainesville, there is no other organization in Florida that provides this level of health professional education in size and scope.

The campus is home to the UF Center for Simulation Education and Safety Research, a state-of-the-art training center spread over two floors of the UF Health Jacksonville Pavilion and the second-largest simulation center in the nation. It also houses Borland Library, one of the three University of Florida health science center libraries.

The Academic Health Center includes a 16,000-square-foot research laboratory building, with space dedicated to translational research, which is focused on bringing discoveries to patients as rapidly as possible. The Jacksonville campus also houses a clinical research unit to perform specialized inpatient studies and has designated resources for extensive outpatient studies.