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Iron deficiency anemia

  • Definition
    • Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues. There are many types of anemia.

      Iron deficiency anemia occurs when your body does not have enough iron. Iron helps make red blood cells. Iron deficiency anemia is the most common form of anemia.

      Reticulocytes
  • Alternative Names
    • Anemia - iron deficiency

  • Causes
    • Red blood cells bring oxygen to the body's tissues. Healthy red blood cells are made in your bone marrow. Red blood cells circulate through your body for 3 to 4 months. Parts of your body, such as your spleen, remove old blood cells.

      Iron is a key part of red blood cells. Without iron, the blood cannot carry oxygen effectively. Your body normally gets iron through your diet. It also reuses iron from old red blood cells.

      Iron deficiency anemia develops when your body's iron stores run low. This can occur because:

      • You lose more blood cells and iron than your body can replace
      • Your body does not do a good job of absorbing iron
      • Your body is able to absorb iron, but you are not eating enough foods that contain iron
      • Your body needs more iron than normal (such as if you are pregnant or breastfeeding)

      Bleeding can cause iron loss. Common causes of bleeding are:

      • Heavy, long, or frequent menstrual periods
      • Cancer in the esophagus, stomach, small bowel, or colon
      • Esophageal varices, often from cirrhosis
      • The use of aspirin, ibuprofen, or arthritis medicines for a long time, which can cause gastrointestinal bleeding
      • Peptic ulcer disease

      The body may not absorb enough iron in your diet due to:

      You may not get enough iron in your diet if:

      • You are a strict vegetarian
      • You are an older adult and do not eat a balanced diet
  • Symptoms
    • You may have no symptoms if the anemia is mild.

      Most of the time, symptoms are mild at first and develop slowly. Symptoms may include:

      • Feeling weak or tired more often than usual, or with exercise
      • Headaches
      • Problems concentrating or thinking

      As the anemia gets worse, symptoms may include:

      Symptoms of the conditions that cause iron deficiency anemia include:

      • Dark, tar-colored stools or blood in the stool
      • Heavy menstrual bleeding (women)
      • Pain in the upper belly (from ulcers)
      • Weight loss (in people with cancer)
  • Exams and Tests
  • Treatment
    • Treatment may include taking iron supplements and eating iron-rich foods.

      Iron supplements (most often ferrous sulfate) build up the iron stores in your body. Most of the time, your provider will measure your iron level before you start supplements.

      If you cannot take iron by mouth, you may need to take it through a vein (intravenous) or by an injection into the muscle.

      Pregnant and breastfeeding women will need to take extra iron because they often cannot get enough iron from their normal diet.

      Your hematocrit should return to normal after 2 months of iron therapy. You will need to keep taking iron for another 6 to 12 months to replace the body's iron stores in the bone marrow.

      Iron-rich foods include:

      • Chicken and turkey
      • Dried lentils, peas, and beans
      • Fish
      • Meats (liver is the highest source)
      • Peanut butter
      • Soybeans
      • Whole-grain bread

      Other sources include:

      • Oatmeal
      • Raisins, prunes, and apricots
      • Spinach, kale, and other greens
  • Outlook (Prognosis)
    • With treatment, the outcome is likely to be good, but it does depend on the cause.

  • When to Contact a Medical Professional
    • Call your provider if:

      • You have symptoms of iron deficiency
      • You notice blood in your stool
  • Prevention
    • A balanced diet should include enough iron. Red meat, liver, and egg yolks are high sources of iron. Flour, bread, and some cereals are fortified with iron. If advised by your provider, take iron supplements if you are not getting enough iron in your diet.

  • References
    • Bope ET, Kellerman RD. Hematology. In: Bope ET, Kellerman RD, eds. Conn's Current Therapy 2016. Philadelphia, PA: Elsevier; 2016:chap 12.

      Brittenham GM. Disorders of iron homeostasis: iron deficiency and overload. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 34.

      Bunn HF. Approach to anemias. In: Goldmann L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 158.