Types of hormone therapy

  • Definition
    • Hormone therapy (HT) uses one or more hormones to treat symptoms of menopause. HT uses estrogen, progestin (a type of progesterone), or both. Sometimes testosterone is also added.

  • Alternative Names
    • HRT- types; Estrogen replacement therapy - types; ERT- types of hormone therapy; Hormone replacement therapy - types; Menopause - types of hormone therapy; HT - types; Menopausal hormone types

  • Menopause and Hormones
    • Menopause symptoms include:

      • Hot flashes
      • Night sweats
      • Sleep problems
      • Vaginal dryness
      • Anxiety
      • Moodiness
      • Less interest in sex

      After menopause, your body stops making estrogen and progesterone. HT can treat menopause symptoms that bother you.

      HT does have some risks. It may increase your risk for:

      • Blood clots
      • Breast cancer
      • Heart disease
      • Stroke

      Despite these concerns, for many women, HT is a safe way to treat menopause symptoms, as long as you take it:

      • No longer than 5 years
      • At the lowest possible dose
  • Forms of Hormone Therapy
    • HT comes in different forms. You may need to try different types before finding one that works best for you.

      Estrogen comes in:

      • Nasal spray
      • Pills or tablets, taken by mouth
      • Skin gel
      • Skin patches, applied to the thigh or belly
      • Vaginal creams or vaginal tablets to help with dryness and pain with sexual intercourse
      • Vaginal ring

      Most women who take estrogen and who still have their uterus also need to take progestin. Taking both hormones together lowers the risk of endometrial (uterine) cancer. Women who have had their uterus removed cannot get endometrial cancer. So, estrogen alone is recommended for them.

      Progesterone or progestin comes in:

      • Pills
      • Skin patches
      • Vaginal creams
      • Vaginal suppositories

      The type of HT your doctor prescribes may depend on what menopause symptoms you have. For example, pills or patches can treat night sweats. Vaginal rings, creams, or tablets help relieve vaginal dryness.

      Discuss the benefits and risks of HT with your health care provider.

  • How you Will Take Hormones
    • When taking estrogen and progesterone together, your doctor may suggest one of the following schedules:

      Cyclic hormone therapy is often recommended when you start menopause.

      • You take estrogen as a pill or use it in patch form for 25 days.
      • Progestin is added between days 10 and 14.
      • You use estrogen and progestin together for the remainder of the 25 days.
      • You don't take any hormones for 3 to 5 days.
      • You may have some monthly bleeding with cyclic therapy.

      Combined therapy is when you take estrogen and progestin together every day.

      • You may have some unusual bleeding when starting or switching to this HT schedule.
      • Most women stop bleeding within 1 year.

      Your doctor may prescribe other medicines if you have severe symptoms or have a high risk of osteoporosis. For example, you may also take testosterone, a male hormone, to improve your sex drive.

  • Side Effects of Hormone Therapy
    • HT can have side effects, including:

      • Bloating
      • Breast soreness
      • Headaches
      • Mood swings
      • Nausea
      • Water retention
      • Irregular bleeding

      Tell your doctor if you notice side effects. Changing the dose or type of HT you take may help reduce these side effects. DO NOT change your dose or stop taking HT before talking with your doctor.

  • When to Call the Doctor
    • If you have vaginal bleeding or other unusual symptoms during HT, call your doctor.

      Be sure to continue seeing your doctor for regular checkups when taking HT.

  • References
    • ACOG Committee Opinion No. 565: Hormone therapy and heart disease. Obstet Gynecol. 2013;121(6):1407-1410. PMID: 23812486

      Cosman F, de Beur SJ, LeBoff MS, et al. Clinician's guide to prevention and treatment of osteoporosis. Osteoporosis Int. 2014;25(10):2359-2381. PMID: 25182228

      de Villiers TJ, Gass ML, Haines CJ, et al. Global consensus statement on menopausal hormone therapy. Climacteric. 2013;16(2):203-204. PMID: 23488524

      North American Menopause Society. The 2012 hormone therapy position statement of: The North American Menopause Society. Menopause. 2012;19(3): 257-271. PMID: 22367731

      Stuenkel CA, Davis SR, Gompel A, et al. Treatment of symptoms of the menopause: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2015;100(11):3975-4011. PMID: 26444994