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Glanzmann disease

  • Definition
  • Alternative Names
    • Glanzmann's diasease; Thrombasthenia - Glanzmann

  • Causes
    • Glanzmann disease is caused by the lack of a protein that is normally on the surface of platelets. This substance is needed for platelets to clump together to form blood clots.

      The condition is congenital, which means it is present from birth. There are several genetic abnormalities that can cause the condition.

  • Symptoms
    • Symptoms may include any of the following:

      • Heavy bleeding during and after surgery
      • Bleeding gums
      • Bruising easily
      • Heavy menstrual bleeding
      • Nosebleeds that do not stop easily
      • Prolonged bleeding with minor injuries
  • Exams and Tests
  • Treatment
    • There is no specific treatment for this disorder. Platelet transfusions may be given to people who are having severe bleeding.

  • Outlook (Prognosis)
    • Glanzmann disease is a lifelong condition, and there is no cure. You should take special steps to try to avoid bleeding if you have this condition.

      Anyone with a bleeding disorder should avoid taking aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen. These drugs can prolong bleeding times by preventing platelets from clumping.

  • Possible Complications
    • Complications may include:

  • When to Contact a Medical Professional
    • Call your health care provider if:

      • You have bleeding or bruising of an unknown cause
      • Bleeding does not stop after usual treatments
  • Prevention
    • Glanzmann disease is an inherited condition. There is no known prevention.

  • References
    • Macartney CA, Paredes N, Chan AKC. Disorders of coagulation in the neonate. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 152.

      Nurden AT, Pillois X, Wilcox DA. Glanzmann thrombasthenia: state of the art and future directions. Semin Thromb Hemost. 2013;39;642-55. PMID: 23929305