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Uterine sarcoma

  • Definition
    • Uterine sarcoma is a rare cancer of the uterus (womb). It is not the same as endometrial cancer, a much more common cancer that starts in the lining of the uterus. Uterine sarcoma most often starts in the muscle underneath that lining.

  • Alternative Names
    • Leiomyosarcoma; Endometrial stromal sarcoma; Undifferentiated sarcomas; Uterine cancer-sarcoma

  • Causes
    • The cause is not known. But there are certain risk factors:

      • Past radiation therapy. A few women develop uterine sarcoma 5 to 25 years after they had radiation therapy for another pelvic cancer.
      • Past or current treatment with tamoxifen for breast cancer.
      • Race. African American women have twice the risk that white or Asian women have.
      • Genetics. The same abnormal gene that causes an eye cancer called retinoblastoma also increases the risk of uterine sarcoma.
  • Symptoms
    • Fibroids in the uterus are a common problem in women. Common symptoms of fibroids include abnormal uterine bleeding, pelvic pain and pressure, and a pelvic mass.

      These symptoms or findings are also the more common symptoms of uterine sarcoma.

      Let your health care provider know as soon as you can about:

      • Any bleeding that is not part of your menstrual period
      • Any bleeding that happens after menopause

      Most likely, the bleeding will not be from cancer. But you should always tell your provider about unusual bleeding.

      Other possible symptoms of uterine sarcoma include:

      • Vaginal discharge that does not get better with antibiotics and may occur without bleeding
      • A mass or lump in the vagina or uterus
      • Having to urinate often
  • Exams and Tests
    • Your provider will take your medical history. You will also have a physical exam and a pelvic exam. Other tests may include:

      Imaging tests are needed to create a picture of your reproductive organs. Ultrasound of the pelvis is often done first. Yet, it often cannot tell the difference between a fibroid and a sarcoma. An MRI scan of the pelvis may also be needed.

      A biopsy using ultrasound or MRI to guide the needle may be used to make the diagnosis.

      If your provider finds signs of cancer, other tests are needed for staging the cancer. These tests will show much cancer there is. They'll also show if it has spread to other parts of your body.

  • Treatment
    • Surgery is the most common treatment for uterine cancer. Surgery may be used to diagnose, stage, and treat uterine sarcoma all at one time. After surgery, the cancer will be examined in a lab to see how far it has progressed.

      Depending on the results, you may need radiation therapy or chemotherapy to kill any cancer cells that remain.

      You also may have hormone therapy for certain kinds of tumors that respond to hormones.

      For advanced cancer that has spread outside the pelvis, you may want to join a clinical trial for uterine cancer.

      With cancer that has come back, radiation may be used for palliative treatment. Palliative care is meant to relieve symptoms and improve a person's quality of life.

  • Support Groups
    • Cancer affects how you feel about yourself and your life. You can ease the stress of illness by joining a cancer support group. Sharing with others who have had the same experiences and problems can help you feel less alone.

      Ask your provider or the staff at the cancer treatment center to help you find a support group for people who have been diagnosed with uterine cancer.

  • Outlook (Prognosis)
    • Your prognosis depends on the type and stage of uterine sarcoma you have when treated. For cancer that has not spread, at least 2 out of every 3 people are cancer-free after five years. The number drops once the cancer has started to spread and becomes harder to treat.

      Uterine sarcoma is often not found early. Your provider can help you understand the outlook for your type of cancer.

  • Possible Complications
    • While unlikely, complications may include:

      • A perforation (hole) of the uterus may occur during a D and C or endometrial biopsy
      • Complications from surgery, radiation, and chemotherapy
  • When to Contact a Medical Professional
    • See your provider if you have any symptoms of uterine cancer.

  • Prevention
    • Because the cause is unknown, there's no way to prevent uterine sarcoma. If you have had radiation therapy in your pelvic area or have taken tamoxifen for breast cancer, ask your provider how often you should be checked for possible problems.

  • References
    • El-Khalfaoui K, du Bois A, Heitz F, Kurzeder C, Sehouli J, Harter P. Current and future options in the management and treatment of uterine sarcoma. Ther Adv Med Oncol. 2014 Jan;6(1):21-8. PMID: 24381658

      Gadducci A, Cosio S, Romanini A, Genazzani AR. The management of patients with uterine sarcoma: a debated clinical challenge. Crit Rev Oncol Hematol. 2008 Feb;65(2):129-42. PMID: 17706430

      Hyman DM, Grisham RN, Hensley ML. Management of advanced uterine leiomyosarcoma. Curr Opin Oncol. 2014 Jul;26(4):422-7. PMID: 24840518

      National Cancer Institute: PDQ® Uterine Sarcoma Treatment. Bethesda, MD: National Cancer Institute. Date last modified 12/02/2013. Available at: Accessed: 7/7/2015.